Public Key Infrastructure using X.509 (PKIX) certificates are used for a number of purposes, the most significant of which is the authentication of domain names. Thus, certification authorities (CAs) in the Web PKI are trusted to verify that an applicant for a certificate legitimately represents the domain name(s) in the certificate. As of this writing, this verification is done through a collection of ad hoc mechanisms. This document describes a protocol that a CA and an applicant can use to automate the process of verification and certificate issuance. The protocol also provides facilities for other certificate management functions, such as certificate revocation.
I would recommend against any use of ACME for ATNA based secure node or secure application; and would recommend against use of ACME managed certificate for ANY healthcare traffic, even simple HTTP based traffic.